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Compared with EtOH-fed WT mice, KO mice were less susceptible to EtOH-induced deleterious effects, including body weight loss (reflected by less body weight gain), liver weight gain and hepatocyte damage (reflected by plasma ALT activity) (Table 1)

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One of the most obvious risk factors for KOA is ageing, in which ageing of cartilage and chondrocytes plays an important role in the pathogenesis and development of KOA (Rahmati et al., 2017)