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Our models facilitate the investigation of disease pathology, metabolic dysfunction, and therapeutic strategies, serving as a powerful platform for drug discovery and validation
A similar dietary supplementation was also found to decrease the phosphorylation of PPAR and nuclear factor E2-related factor 2 (Nrf2) and induce upregulation of their downstream targets including -glutathione S-transferase (GST) and adenosine triphosphate-binding cassette transporter A1 (ABCA1) through inhibition of matrix metalloproteinase-1 (MMP-1) (Bozaykut et al., 2014)
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Reduced glutathione is the prosthetic group of glyceraldehyde phosphate dehydrogenase and also a coenzyme of glyoxalase and phosphotriose dehydrogenase
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