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The appetite hormone responses varied by peptide, with an increase in total ghrelin and no changes in total GLP-1 observed in both RCTs and non-RCTs, and inconsistent responses for acylated ghrelin, total PYY and PYY 3-36

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While this peptide is a potent agonist for cAMP production, it is a biased agonist, with a preference for G protein-mediated signalling relative to -arrestin recruitment when compared to GLP-1 and exendin-4 26