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Due to the limited regenerative capability of cartilage tissue, the reconstruction of cartilage in situ remains a considerable challenge

[Crossref] [PubMed] Mollan SP, Mitchell JL, Ottridge RS, et al

The increased expression of SIRT1 and SIRT3 induced by low-level oxidative stress may be the result of a compensatory defense, thus favoring autophagy, which is characterized by increased levels of autophagy marker LC3-II and decreased P62 levels in GCs

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