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Early clinical trials have suggested that it may significantly influence body weight reduction, appetite control, and fat metabolism

GLP-1 receptor agonists can stimulate GLP-1 receptors in the area postrema, a circumventricular organ in the lower brainstem that has fenestrated capillaries and can sense hormonal signals in the general circulation, and appetite centres in the hypothalamus, which has fenestrated capillaries in the median eminence

When initiating OZEMPIC, consider reducing the dose of concomitantly administered insulin secretagogue (such as sulfonylureas) or insulin to reduce the risk of hypoglycemia [see Warnings and Precautions (5.5), Adverse Reactions (6)]