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Although several observational real-world studies of semaglutide OW have been undertaken [21,22,23,24,25,26,27,28,29,30,31], evidence concerning its relative effectiveness versus other interventions (including SGLT2is) in the real-world setting is limited

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Afferent and efferent innervation of the hindbrain GLP-1-producing neurons Unlike many of its gut or fat hormone counterparts (ghrelin or leptin) for which there is little evidence of central production, GLP-1 can be made in the brain

doi: 10.1002/adfm.202409707 193 ShengWLiaoSCaoSWeiYZhaoJYueYet al