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Laboratory studies demonstrate that ES2 peptides show 3-7 times more potent senolytic activity than FOXO4-DRI in both in vitro and in vivo experimental systems, while CPP-CAND demonstrates approximately 1.2-fold higher selectivity despite shorter peptide length

Notably, there was a significant decrease (7.5%) in AA in striatal tissues but a significant increase (18%) in SNcVTA tissues in mutants compared with controls (Fig

Hypothalamic-Pituitary and growth disorders in survivors of childhood cancer: an endocrine society clinical practice guideline

Understanding the complex relationship between gut microbiota and cancer may lead to novel approaches for prevention, early detection, and treatment ( The review highlights the current understanding of the immune system, gut microbiota, and their potential roles in cancer immune surveillance