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RYBELSUS : A1C reduction demonstrated at 52 weeks Statistically significant A1C reduction vs Jardiance 2* Statistically significant A1C control vs Jardiance 2* PIONEER 2 study design 1,2 In an open-label trial with a primary endpoint of mean change in A1C from baseline to 26 weeks, 822 adult patients with type 2 diabetes on metformin were randomized to RYBELSUS 14 mg (n=411) or Jardiance 25 mg (n=410), both once daily