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The AACE/ACE obesity clinical practice guidelines recommend treating obesity as a chronic disease requiring long-term pharmacological management when lifestyle intervention alone is insufficient, and explicitly note that comorbidity burden should guide medication selection throughout the treatment course

This combination typically reduces HbA1c by 1020 mmol/mol with minimal hypoglycaemia risk compared to insulin-based regimens

[6] Similarly, observational studies using healthcare databases have suggested that patients prescribed GLP-1 agonists for diabetes or obesity appear to have lower rates of alcohol-related hospital admissions and reduced self-reported drinking compared to those on other medications, though these findings are limited by potential confounding factors

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