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This reduction in may lead to the translocation of Parkin to mitochondria, where it ubiquitinates Mfn1 and Mfn2, thereby targeting these proteins for proteasomal degradation and finally leading to removal of damaged mitochondria during mitophagy (Ni et al

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This suggests that different HTPs with different heating characteristics and/or different tobacco stick compositions may elicit dissimilar subjective effects and therefore differentially provide support to different smokers switching away from cigarette smoking