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P = 0.51), BMI (SMD: 0.025

A prospective randomized controlled open trial of 75 breast cancer patients showed that oral NAC (1200 mg once and twice daily) was effective in reducing the incidence and severity of paclitaxel-induced peripheral neuropathy, accompanied by increased serum nerve growth factor (NGF) levels and decreased malondialdehyde (MDA) levels, which could prevent grade 3 neurotoxicity [68]