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Safety Considerations and Who Should Pursue GLP-1 Therapy GLP-1 agonists are generally well-tolerated, with the most common side effects being gastrointestinal: nausea, vomiting, and diarrhea, typically mild and transient

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In a study of 1617 human fecal samples (Karcher et al., 2021), AmI accounted for the highest proportion (47%), followed by AmII and AmIII (27 and 24%, respectively)