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As Gpx4 requires glutathione as a substrate, ferroptosis is also induced by disruption of glutathione supply via inhibition of glutathione synthesis (e expression is critical to protection against acute lung injury in mice

The plant exhibits biphasic vasorelaxation: its immediate effect is due to endothelium-dependent NO release, while the delayed effect results from the inhibition of voltage-dependent CCs (VDCCs) and receptor-operated CCs (ROCCs), which prevents Ca 2+ influx (268)

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