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144 However, apelin enhances glucose uptake and Akt phosphorylation through AMPK pathway to improve glucose homeostasis and insulin sensitivity, 145 apelin deficient mice are insulin resistant and have decreased skeletal muscle Akt phosphorylation

Applications in ObesityRelated Pathological Mechanism Research Advancing Research on the Pathogenesis of NonAlcoholic Fatty Liver Disease Nonalcoholic fatty liver disease is another major obesityrelated complication, marked by excessive hepatic fat accumulation, which can progress to cirrhosis and liver cancer in severe cases

If the cell overheats quickly, they know that rating is too high