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Oral administration creates slower absorption with sustained but lower peak concentrations due to first-pass metabolism, which may reduce the need for daily dosing as the compound remains bioavailable for extended periods

In addition, there was evidence of a significant reduction in average loop diuretic dose, a lower likelihood of diuretic treatment escalation, and a greater likelihood of diuretic treatment de-escalation with semaglutide versus placeboparameters that indicate disease-modifying effects of semaglutide, and are associated with better long-term clinical outcomes in this patient population. Photo 288328289 Fernanda Carrasco | Dreamstime.com