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Eligibility criteria for selecting studies: Prospective cohort studies with at least 50 events, reporting hazard ratios or relative risks (both hereafter referred to as relative risk) compared with never smokers or age specific incidence in relation to risk of coronary heart disease or stroke

This may continue to be a growing problem where e-cigarettes have become a $2.2 billion industry and the use is climbing among adults and teens, according to federal statistics

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