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Data Animal Data Intranasal administration of dihydroergotamine mesylate to pregnant rats throughout the period of organogenesis resulted in decreased fetal body weight and/or skeletal ossification at doses of 0.16 mg/day and greater

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The Treated group received a 5-day oral treatment course of 100 mg/kg phenformin (once daily for 5 days, D-2 to D2), whereas the Vehicle group received sterile water