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Fue el nico frmaco asociado a reducciones estadsticamente significativas de la mortalidad por cualquier causa (19%), el infarto de miocardio (28%) y la insuficiencia cardiaca (57%)

[DOI] [PMC free article] [PubMed] [Google Scholar] 88.Pea-Bautista C., Vento M., Baquero M., Chfer-Perics C

In vivo, mutant clones expand over a period of months to years, to multi-millimeter sizes competing for the limited space available in homeostatic epithelia 27,28,29,30,31,32

The method of any one of embodiments 118-137, wherein the composition comprises between about 0.0001% to about 20% by weight of the therapeutic agent, about 0.0001% to about 15% by weight of the therapeutic agent, about 0.0001% to about 10% by weight of the therapeutic agent, about 0.0001% to about 5% by weight of the therapeutic agent therapeutic agent, or about 0.0001% to about 1% by weight of the therapeutic agent