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The most commonly reported adverse effects include gastrointestinal symptoms such as nausea, vomiting, diarrhoea, and constipation, which typically diminish over time

By inducing ROS accumulation, modulating mitochondrial membrane potential, and activating oxidative stress-related pathways, the nanozyme suppresses tumor proliferation and restores sensitivity to chemotherapeutic agents such as 5-FU [101]

Eligibility requirements vary, so patients should research available trials in the St George area

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