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(iii) Safety Endpoints: Rare events and data scarcity place the posterior in a gray zone, best presented through probabilistic language that defines the boundaries of risks that can neither be confirmed nor excluded ( Consequently, clinical communication can shift from binary assertions (effective/ineffective, safe/unsafe) to a framework of probabilities + intervals + acceptance thresholds. For instance, the posterior probability of reaching a clinically meaningful weight-loss threshold can be presented alongside the posterior uncertainty of benefits in hard reproductive endpoints, rather than replacing the decision process with a single P -value

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virtually all gray matter areas can be involved including cerebral cortex, hippocampus, deep gray matter nuclei, cerebellum and even spinal gray matter (Calabrese et al., 2015