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2,339 participants randomized to 4 mg, 9 mg, 12 mg, or placebo: Placebo: 3.9% weight loss 4 mg: 17.6% average weight loss (~37 lbs) 9 mg: 23.7% average weight loss (~54 lbs) 12 mg: 2528.3% average weight loss (~70 lbs) 45.3% of participants achieved 30% weight loss At 104 weeks, participants with severe obesity on 9 mg or 12 mg achieved up to 30% total body weight loss a threshold historically associated only with bariatric surgery