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This is needed for glutathione to function as an antioxidant and explains how riboflavin deficiency can depress its function [52]
Exendin-4 (3 and 10 g/kg/day) treatment significantly downregulated the gene expression of CD14, ICAM-1, and TGF 1 in the renal cortex, prevented glomerular macrophage infiltration in glomeruli, and reduced oxidative stress and inflammation in tubular cells in STZ-induced diabetic animals [101, 103]