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Apomorphine Unlike PDE5 inhibitors, which work to control enzymatic activities that influence blood flow, apomorphine works in the brain as a dopamine receptor agonist, which essentially tricks the brain into behaving as though theres more dopamine present than there is in fact.36 Dopamine a critical neurotransmitter plays important roles in male sexual health and behavior, with imbalances in neurochemistry that contribute to ED earning their own designation as neurogenic erectile dysfunction .37 23 Including apomorphine in an ED treatment regimen can help offset neurochemical imbalances that might be contributing to or even be the root cause of ED