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Despite these extensive and promising neuroprotective effects, Ruts journey to clinical application faces some challenges, such as its relatively low bioavailability, chemically unstable under certain conditions, including light, heat, and pH, pharmacokinetic limitations, interact with other medication could either reduce Ruts effectiveness or increase the risk of adverse effects and its safety profile with long-term use or at high doses (Ozkan et al

Ongoing trials on plant-derived compounds continue to pave the way for translational applications, reinforcing the viability of natural product-based interventions

This could potentially unlock the systemic therapeutic potential of GHK-Cu in ways that are currently unachievable

A 2003 meta-analysis of 21 trials found that ALCAR was superior to placebo in several psychometric tests assessing global patient functioning, attention, memory, and some intellectual functions (105)