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Choose Injection Sites With Adequate Subcutaneous Tissue Injection sites with minimal subcutaneous fat, such as the inner thigh, the lower abdomen in leaner individuals, or areas close to bony prominences, offer less tissue cushioning between the needle and sensory nerve endings

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However, because the brain uses the same dopamine pathways for other rewards (like shopping, alcohol, or even social interaction), some researchers believe the drug may act as a general reward dampener