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J Invest Dermatol 87 (1): 4-10 (1986) Clotrimazole was given by mouth in a dose of 1.5 g to 7 healthy subjects and 47 patients and peak blood concentrations of up to 1 ug/ml were detected microbiologically at 2 or 4 hours

Notably, the mechanism effectively avoids the formation of alkyl radicals or byproducts, which are typically associated with radical reactions involving acyl radicals

At baseline and at 2-, 4-, 6-, and 8 weeks, skin hydration (by a skin capacitance meter) and skin elasticity (by a cutometer) were quantified

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