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For example, human umbilical vein endothelial cells derived from the umbilical cords of patients with GDM exhibited impaired NRF2 activation in the presence of the reactive lipid 4-hydroxynonenal, which was associated with decreased NQO1, xCT, and GCLM levels, depleted GSH, and a marked increase in reactive species production and subsequent protein oxidation (80)

Dishes felt elevated but still approachable