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Virus transfection IGF-1 treated SCAPs were transfected with hsa-let-7c over/low-expression lentiviruses (Shanghai Genechem Co., LTD, Shanghai, China) and thus four groups were applied in this study, i.e., Con-over group (cells transfected with over-expression control vectors), Let-7c -over group (cells transfected with hsa-let-7c over-expression lentivirus), Con-low group (cells transfected with scramble control vectors) and Let-7c -low group (cells transfected with hsa-let-7c low-expression lentivirus)

3 (ClinicalTrials.gov )

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