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For more on the medicine itself, do oral GLP-1s really work offers a useful comparison

PubMed Aronne, L.J., Sattar, N., Horn, D.B., Bays, H.E., Wharton, S., Lin, W.Y., Ahmad, N.N., Zhang, S., Liao, R., Bunck, M.C., Jouravskaya, I., Hesse, D., Jastreboff, A.M., & SURMOUNT-1 Investigators

Liu showed a video of a young girl so debilitated that, before the procedure, she was flat on her back and had trouble forming words

For Ozempic (multi-dose pen with detachable needles): Remove the pen from refrigeration 1530 minutes before injection to reduce discomfort Wash hands thoroughly with soap and water Attach a new needle for each injection Perform a flow check before first use of each new pen only (not before every dose) Clean the injection site with an alcohol swab and allow to dry completely For Wegovy (single-dose pen with built-in needle): Remove the pen from refrigeration 1530 minutes before injection Wash hands thoroughly Do not prime the pen (it comes ready to use) Clean the injection site with an alcohol swab and allow to dry completely Injection technique for both products: Pinch a fold of skin gently between thumb and forefinger to elevate subcutaneous tissue away from underlying muscle