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Toxicological evaluation of Vernonia amygdalina methanol leave extract in rats

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They can affect the survival, proliferation, metastasis, recurrence, drug resistance, and other functions of tumor cells through altering the function, activity, subcellular localization, protein-protein interactions, protein stability, other modification levels of non-histone proteins, and modifying histones to change gene expression, chromatin accessibility, transcriptional activity, all of which are closely related to the initiation and progression of tumors

This is especially the case if blood sugar is not well controlled after lifestyle changes