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Nat Rev Neurosci 8:171181

While it is perhaps somewhat surprising that no group differences in metabolite concentrations were found, either for GABA (as has been shown before) or for GSH, we note that autism is an extremely heterogeneous condition, and that group differences, if present, may be small and relatively uninformative in understanding the broader autism phenotype(Loth et al., 2021)

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Therefore, data elements unrelated to the trial's exposure and outcome, such as anti-infective medications and symptom diagnoses in our study, may be underrepresented