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As mentioned, infectious mononucleosis caused by EBV is a risk factor for various autoimmune diseases (487, 497), and may play a potential role in ME/CFS (140, 498500)

As regards the pathogenic mechanisms, the occurrence of an oxidant stress (resulting from an impaired homocysteine metabolism, which modifies the redox status of extra- and intracellular thiols and thus alters the intracellular redox potential) might play a central role in moderate hyperhomocysteinemia-mediated vascular disorders

The needle remained in place for an additional 10 min to facilitate diffusion, followed by careful withdrawal and surgical closure

However, based on our results mutants abolished in glutathione biosynthesis failed to accomplish this mission