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For instance, upregulating GPX4 in ferroptosis-sensitive chondrocytes, restoring antioxidant defenses in inflammatory synovial macrophages, or rebalancing iron export in subchondral osteoblasts may prevent tissue-specific degeneration

Corticosteroids Corticosteroids provide rapid symptom relief but carry substantial risks: immunosuppression, impaired wound healing, tendon weakening with increased rupture risk, hyperglycemia, and osteoporosis with chronic use

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In addition to this study in patients with bronchiectasis, studies of brensocatib in other indications, such as CRSsNP (NCT06013241), are underway