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Some came close to making the cut with research-backed strains and ease of swallowing, while others fizzled out due to high price tags or lack of quality assurance

A higher incidence of gastrointestinal adverse effects was reported in participants treated with tirzepatide, compared with those treated with degludec [127]

Pharmaceutical GLP-1 analogs work by mimicking and extending the activity of this natural hormone - producing the appetite-suppressing and metabolic effects at sustained concentrations that the natural hormone, which is rapidly degraded by the enzyme DPP-4, can't maintain on its own

With a wide range of plausible effectiveness and costs of behavioral intervention, this alternative program was projected to generate substantial savings in net healthcare costs, with minimal loss of health-related quality of life