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When to seek medical attention: Persistent vomiting preventing adequate fluid intake Severe abdominal pain, particularly if localized to the upper right quadrant (potential gallbladder issues) Severe pain in the upper abdomen radiating to the back (possible pancreatitis) Signs of dehydration (dark urine, dizziness, decreased urination) Inability to tolerate any food or liquids for more than 24 hours Severe constipation with abdominal distension or vomiting (possible ileus/obstruction) Yellowing of skin/eyes with fever and abdominal pain Patients with significant vomiting or diarrhea should be monitored for signs of acute kidney injury, particularly those with pre-existing renal impairment or taking medications that affect kidney function

This may be related to the impact on the brains reward system, as GLP-1s are expressed in areas of the brain influenced by addictive drugs, such as nicotine, opioids, and alcohol

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Available under the brand name Mounjaro, this medication has shown strong results in helping people lose weight by managing appetite and blood sugar levels