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Wound Healing, Skin Repair, and Regeneration Research A multicenter, randomized, evaluator-blinded, placebo-controlled study in diabetic neuropathic ulcers reported greater median plantar-ulcer closure with topical glycyl-L-histidyl-L-lysine copper gel compared with vehicle, 98.5% versus 60.8%, and lower ulcer infection incidence, 7% versus 34% [3]

Animal Model:Klotho-hypomorphic mice (kl/kl mice) [2] Dosage:80 mg/L Administration:Oral gavage (p.o.) Result:Increased mouse lifespan, did not significantly improve hypercalcemia, hyperphosphatemia or excess 1,25(OH) 2 D 3 and FGF23 plasma concentrations, reduced tissue calcification in kl/kl mice, reduced PIT1, osteoblast differentiation Promoter for expression of Tnfa, Alpl, Msx2, Cbfa1, Osx

Matthew Koch, R-Paris

2016;39:e223