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L., DiNicolantonio, J

Since its founding in 1890, the Steinhardt School's mission has been to expand human capacity through public service, global collaboration, research, scholarship, and practice

These immune cells exacerbate tissue injury through cytotoxicity and the release of inflammatory mediators, and are closely associated with the development of emphysema ( FIGURE 1 Cellular senescence, the senescence-associated secretory phenotype (SASP), miR-34a, and sirtuins (SIRT1/6) Chronic inflammation and oxidative stress induce epithelial cells, fibroblasts, and endothelial cells into a senescent phenotype through the ATM/ATR-p53/p21 pathway ( In summary, the inflammation-senescence axis drives the progression of small airway disease toward COPD, forming a vicious cycle

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