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Notably, in the context of anti-tumor therapy, GLUT3 is highly expressed in highly aggressive tumors, particularly brain tumors, making it a promising therapeutic target for glioblastoma and brain metastases

Peroxiredoxin 6, a 1-Cys peroxiredoxin, functions in antioxidant defense and lung phospholipid metabolism

However, the role of p53 in regulation of IGF-1R seems to be more complex and probably also involves post-transcriptional mechanisms (Girnita et al, 2000

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