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This is caused by an imbalance between factors that relax the endothelium, such as nitric oxide (NO), prostacyclin (PGI 2 ), and down regulation of endothelioum-dependent hyperpolarization (EDH) and factors that cause contraction such as thromboxane A 2 (TxA 2 ) and upregulation of endothelin-1 (ET-1)

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Vitamin D deficiency is more commonly found in people with Hashimotos 68 percent of my readers with Hashimotos reported also being diagnosed with vitamin D deficiency , and 67 percent saw improvement in energy from increasing their vitamin D levels