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There was no evidence of a carcinogenic effect in mice administered varenicline by oral gavage for 2 years at doses up to 20 mg/kg/day (47 times the maximum recommended human daily (MRHD) exposure based on AUC)
Ralph Hattox, Coffee and Coffeehouses: The Origins of a Social Beverage in the Medieval Near East (1985) Hattoxs Coffee and Coffeehouses is a classic, which provides a fabulous overview of the introduction of coffee into global consumer cultures
Reactive oxygen species induced p53 activation: DNA damage, redox signaling, or both
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