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Adults usually develop symptoms in folds of skin and wherever clothing causes friction Morphology - small, clear, vesicles that break easily This type of heat rash usually clears on its own but can come back if hot, humid weather persists Leg oedema (figures 9-10) Oedema / lymphoedema , with or without cellulitis , is a common cause of bullae It is important to manage the underlying cause Dressing may be required - refer to the section on Leg dressings and other bandaging techniques Infection Bacterial infection Bullous impetigo (figures 11-13) Usually caused by streptococcus pyogenes and / or staphylococcus aureus Small or large bullae arise over a short period of time , usually spreading locally on the face, trunk, extremities, buttocks, or perineal regions and may reach distal areas Bullae are fragile and burst spontaneously to leave a yellow crust that usually heals without scarring Refer to the chapter Bullous impetigo Cellulitis (figure 14) Usually caused by streptococcus pyogenes and / or staphylococcus aureus Commonly affects a limb but can occur anywhere on the body The underlying skin is erythematous and feels hot

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Since these design changes do not involve words, they allow tobacco companies to evade laws and regulations designed to prevent the companies from manipulating consumers

various laser-based and other fast mass spectrometry), real-time smoke analyses with improved LODs and LOQs have become more accessible