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This is because bacteria developed most of the antibiotics we use today millennia ago, and at the same time, other bacteria were evolving ways to defend themselves and resist them

HowesODMcCutcheonRAgidOde BartolomeisAvan BeverenNJBirnbaumMLet alTreatment-resistant schizophrenia: treatment response and resistance in psychosis (TRRIP) working group consensus guidelines on diagnosis and terminology

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Some EU countries plan to bring that deadline forward