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Shanghai Science and Technology Development Funds 18ZR1447800 (L.H.Z.) and 18431907100 (M.-W.W.)

Glucagon-like peptide-1 (GLP-1) receptor agonists are injectable medications approved by the FDA for type 2 diabetes management and, in some formulations, chronic weight management

Focus areas: Increase protein intake to 1.2 to 1.4 grams per kilogram of body weight Add a B-complex vitamin supplement if not already taking one Introduce resistance training twice per week if energy permits Monitor hydration strictly, aiming for pale yellow urine at all times If fatigue is severe, eat more calorically dense foods rather than trying to increase food volume Many people stay at 5 mg as their maintenance dose if they are losing weight effectively and tolerating the medication well