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People with a history of B6-related peripheral neuropathy should avoid additional supplementation
According to the Mounjaro Summary of Product Characteristics (SmPC), gastrointestinal disorders are very common side effects, with dyspepsia and gastro-oesophageal reflux disease specifically listed among the adverse reactions
The theory is that continuous high-dose GLP-1 agonist exposure can lead to partial receptor desensitization, and a brief period at a lower dose allows the receptors to upregulate
Technical considerations include proper patient positioning in right lateral decubitus, antral cross-sectional area measurement, and qualitative assessment categorising gastric contents as empty, clear fluid, or thick fluid/solids [60]
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