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What Exactly Is Tirzepatide and How Does It Work Tirzepatide is a 39-amino acid synthetic peptide classified as a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist

JAMA Surgery study of 1,046 patients identified independent risk factors for food retention with GLP-1 RA use (odds ratio 9.19, 95% confidence interval 2.7330.8), with tirzepatide demonstrating the strongest association amongst available agents [33]

JAMA Internal Medicine analyzed 18,386 matched pairs in a retrospective EHR cohort and found tirzepatide at 15.3% and semaglutide at 8.3% weight loss at 12 months

The companys collaboration with Novo will focus on single- and multiple-receptor-targeting drugs, exploring all possible binding sites