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By 5 mg, the sustained signal approaches the peak produced by a large meal. In diabetes trials, every dose improved insulin sensitivity while reducing the amount of insulin needed. GIP also activates an anti-nausea circuit in the brainstem, which helps offset some of the gastrointestinal burden created by GLP-1. GLP-1R: appetite, tolerability, and heart rate The GLP-1 arm carries appetite suppression, slower stomach emptying, most nausea, and part of the heart-rate signal

Recall significant clinical benefits of DPP-4 inhibitors and recognize potential adverse effects that may occur with initiation of sitagliptin, saxagliptin, linagliptin, or alogliptin

Aim for 0.7-1 gram of protein per pound of your goal body weight daily

Expression of the CT/CGRP gene and its regulation by dibutyryl cyclic adenosine monophosphate in human osteoblastic cells