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As such, it is plausible to hypothesize that maternal smoking or nicotine exposure during pregnancy may influence ones risk for developing ASD [116]

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Kim HS, Yoo HJ, Lee KM, Song HE, Kim SJ, Lee JO, et al

More specifically, given genetic instruments cannot be influenced by other confounders (i.e., lifestyle, or environmental factors), MR studies, are in theory, less susceptible to confounding or reverse causality than traditional observational studies 23