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GO-4 has the following primary mechanism of action: Melphalan cross-links cancer cell DNA, which kills the cancer cell if the cross-link is not repaired

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In addition to their antioxidant properties, polyphenols exhibit anti-atherosclerotic, hypolipidemic, and antibacterial activities (Table 2)

Administration of NRF2 activator, which would be favorable for reinvigorating anti-tumor immunity and conferring the metabolic liabilities on cancer cells, in combination with inhibitors of glutamate and/or NEAA synthesis may be an effective anti-tumor therapy from the viewpoint of interaction between cancer cells and their microenvironment