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Polyphyllin VI has been confirmed to have significant hepatotoxicity on HepaRG liver stem cells showing that it increased the production of ROS, prompted cytochrome c to be released from mitochondria to the cytoplasm, and activated a series of proteins (such as Fas, caspase-3, caspase-8, caspase-9, and poly (ADP-ribose) polymerase), resulting in causing morphological changes and inducing apoptosis

Standard capsules often break down in the stomach, while liposomal formats protect the nutrient for better cellular uptake

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Some studies suggest that glutathione may inhibit melanogenesis by interfering with the activity of tyrosinase, an enzyme critical for melanin synthesis, which has led to its use in skin-lightening protocols