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For example, patients weighing under 200 pounds were restricted to 1,200 kcal per day, patients weighing more than 300 pounds were restricted to 1,800 kcal per day, and for patients between 200 pounds and 300 pounds, body weight (in pounds) was multiplied by 6 to arrive at the daily caloric restriction

Key considerations include: Heart rate increases: These medications may increase resting heart rate, typically by 2-4 beats per minute on average, though some patients may experience increases of 10 beats per minute or more [1] [2] Hypotension risk: Weight loss and volume depletion may affect blood pressure, particularly in patients taking antihypertensive medications Drug interactions: Delayed gastric emptying may affect absorption of some oral medications

Lipedema is a disease that effects fat accumulation, and it does often cause pain, heaviness and tenderness in the affected limbs

Leggio is Chief of the joint NIDA/NIAAA Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section